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| PLAYER | OPPONENT | COMMENTS | |
| 1. |
Kurt Warner Cardinals |
Green Bay | Opponent rating: 17. (Higher the number, weaker the defense.) |
| 2. |
Tom Brady Patriots |
At Houston | 14. |
| 3. |
Aaron Rodgers Packers |
At Arizona | 13. |
| 4. |
Matt Schaub Texans |
New England | 10. |
| 5. |
Ben Roethlisberger Steelers |
At Miami | 26. |
| 6. |
Brett Favre Vikings |
New York Giants | 27. |
| 7. |
Donovan McNabb Eagles |
At Dallas | 15. |
| 8. |
Joe Flacco Ravens |
At Oakland | 19. |
| 9. |
Tony Romo Cowboys |
Philadelphia | 16. |
| 10. |
Drew Brees Saints |
At Carolina | 4. |
| 11. |
Jay Cutler Bears |
At Detroit | 32. |
| 13. |
Alex Smith 49ers |
At St. Louis | 25. |
| 14. |
David Garrard Jaguars |
At Cleveland | 21. |
| 15. |
Eli Manning Giants |
At Minnesota | 23. |
| 16. |
Matt Ryan Falcons |
At Tampa Bay | 28. |
| 17. |
Matt Hasselbeck Seahawks |
Tennessee | 30. |
| 17. |
Philip Rivers Chargers |
Washington | 8. |
| 19. |
Chad Henne Dolphins |
Pittsburgh | 20. |
| 20. |
Derek Anderson Browns |
Jacksonville | 31. |
| 21. |
Vince Young Titans |
At Seattle | 28. |
| 22. |
Kyle Orton Broncos |
Kansas City | 22. |
| 22. |
Peyton Manning Colts |
At Buffalo | 2. |
| 23. |
Carson Palmer Bengals |
At New York Jets | 1. |
| 24. |
Mark Sanchez Jets |
Cincinnati | 12. |
| 25. |
Matt Cassel Chiefs |
At Denver | 5. |