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| PLAYER | OPPONENT | COMMENTS | |
| 1. |
Michael Vick Eagles |
Washington | Mr. Fantasy's opponent rating: 13 (higher the number, weaker the defense). |
| 2. |
Philip Rivers Chargers |
At Oakland | 24. |
| 3. |
Tom Brady Patriots |
Buffalo | 23. |
| 4. |
Tony Romo Cowboys |
At New York Giants | 28. |
| 5. |
Drew Brees Saints |
Carolina | 26. |
| 6. |
Cam Newton Panthers |
At New Orleans | 29. |
| 7. |
Eli Manning Giants |
Dallas | 13. |
| 8. |
Matt Ryan Falcons |
Tampa Bay | 30. |
| 9. |
Tim Tebow Broncos |
Kansas City | 17. |
| 10. |
Matthew Stafford Lions |
At Green Bay | 14. |
| 11. |
Kyle Orton Chiefs |
At Denver | 31. |
| 13. |
Ryan Fitzpatrick Bills |
At New England | 27. |
| 14. |
Rex Grossman Redskins |
At Philadelphia | 19. |
| 15. |
Carson Palmer Raiders |
San Diego | 22. |
| 16. |
John Skelton Cardinals |
Seattle | 5. |
| 16. |
Mark Sanchez Jets |
At Miami | 25. |
| 17. |
Joe Flacco Ravens |
At Cincinnati | 9. |
| 17. |
Josh McCown Bears |
At Minnesota | 18. |
| 18. |
Matt Flynn Packers |
Detroit | 12. |
| 19. |
T.J. Yates Texans |
Tennessee | 11. |
| 20. |
Andy Dalton Bengals |
Baltimore | 1. |
| 22. |
Dan Orlovsky Colts |
At Jacksonville | 10. |
| 23. |
Christian Ponder Vikings |
Chicago | 18. |
| 24. |
Alex Smith 49ers |
At St. Louis | 8. |
| 25. |
Charlie Batch Steelers |
At Cleveland | 6. |